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Recombinant Human TGF-β3 Protein-T&L T&L

Name: Recombinant Human TGF-β3 Protein-T&L T&L Browse our collection of products that will help you to be the very best version of yourself
SKU: mode_7522632564917
Price: 120.00 USD
Availability: InStock

Original price was: $ 400,00.Current price is: $ 120,00.

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SKU: mode_7522632564917 Category: Uncategorized Tag: protein

Product Information

Protein sequence	A DNA sequence encoding the human TGF-β3 (P10600 A301-S412) was expressed with a Fc-tag at the C-terminus
Expression Host	HEK293 cells
QC Testing Purity	> 90 % as determined by SDS-PAGE
Activity	Determined by the dose-dependent stimulation of the inhibitory proliferation of IL-4 – dependent mouse HT-2 cells. The expected ED₅₀ for this effect is ≤ 0.1 ng/ml
Endotoxin Level	< 0.1 EU per 1 μg of the protein by the LAL method
Molecular Mass	The recombinant human TGF-β3 protein consists of 375 amino acids and predicts a molecular mass of 42.1 kD
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 6 % mannitol are added as protectants before lyophilization
Stability & Storage	24 months at 2 °C to 8 °C in lyophilized state. 6 months at -20 °C under sterile conditions after reconstitution. 12 months at -80 °C under sterile conditions after reconstitution. Recommend to aliquot the protein into smaller quantities after reconstituting with water for injection, normal saline or PBS, and keep the diluted concentration above 100 µg/mL. Avoid repeated freeze-thaw cycles.

Background

Transforming growth factor-β (β1, β2 and β3 subtypes) of mammals emit signals through the same receptor, causing similar biological reactions. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation, and motility, as well as the synthesis and deposition of extracellular matrix. They participate in various physiological processes, including embryogenesis, tissue remodeling, and wound healing. They are mainly secreted in the form of potential complexes and stored on the cell surface and extracellular matrix. Release of biologically active transforming growth factor-β isoforms from potential complexes, including proteolysis, processing of complexes, and/or Thrombin reaction reagin-1 conformational changes in proteins. The physiological role of TGF-β3 is not yet clear, but its expression pattern suggests that it plays a regulatory role in certain developmental processes.

References

Developmental pathways of periodontal tissue regeneration: Developmental diversities of tooth morphogenesis do also map capacity of periodontal tissue regeneration? Ripamonti U.J Periodontal Res. 2018 Sep 12. doi: 10.1111/jre.12596.
Integrin β3 Mediates the Endothelial-to-Mesenchymal Transition via the Notch Pathway.Wang W, Wang Z, Tian D, Zeng X, Liu Y, Fu Q, Liang A, Zhang Y, Gao Q, Cheng J, Wang Y.Cell Physiol Biochem. 2018 Sep 7;49(3):985. doi: 10.1159/000493229.
Development and in vitro evaluation of chitosan based system for local delivery of atorvastatin for treatment of periodontitis.Işılay Özdoğan A, Akca G, Şenel S.Eur J Pharm Sci. 2018 Aug 29;124:208-216. doi: 10.1016/j.ejps.2018.08.037.

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Recombinant Human TGF-β3 Protein

Recombinant Human TGF-β3 Protein_SDS

Size	50μg

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Returns

The stock market is always changing. It is not managed entirely by us, as we're involved with several parties such as the factory and our storage. The levels of stock can change at any given time. Be aware that it is possible for your order to run out of stock even after you have placed the order.

The policy is 30 days. However, if 30 days have passed since you purchased your item, we will not be able to offer you a return or exchange.

To be eligible for a refund the item must be in good condition and in the same state as when you received it. It should also be in the original package.

Recombinant Human TGF-β3 Protein-T&L T&L

Product Information

Background

References

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