Recombinant Human IL-18 Protein-T&L T&L

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Background

IL-18 is a proinflammatory cytokine that plays an important role in NK cell activation and Th1 cell response. It is expressed as a 24 kDa precursor by endothelial and epithelial cells, keratinocytes, γδ T cells, and phagocytes. IL-18 is related to the IL-1 family in terms of both structure and function. In terms of structure, IL-18 and IL-1β share significant primary amino acid sequences and are similarly folded as all-beta pleated sheet molecules. Like IL-1β, IL-18 is synthesized as a biologically inactive precursor molecule lacking a signal peptide. In the presence of IL-1β or IL-23, IL-18 induces the antigen-independent production of IL-17 by gamma δ T cells and CD4+ T cells (11). IL-18 also promotes myeloid dendritic cell maturation and triggers neutrophil respiratory burst (12, 13). In cancer, IL-18 exhibits diverse activities including enhancing anti-tumor immunity, inhibiting or promoting angiogenesis, and promoting tumor cell metastasis.

References

1. Çakır M, Tekin S, Taşlıdere A, Çakan P, Düzova H, Gül CC (2011) Protective effect of N-(p-amylcinnamoyl) anthranilic acid, phospholipase A2 enzyme inhibitor, and transient receptor potential melastatin-2 channel blocker against renal ischemia-reperfusion injury. Cell Biochem. 2018J Cell Biochem, 120(3):3822-3832.

2. Xu F, Sang W, Li L, He X, Wang F, Wen T, Zeng N. (2019) Protective effects of ethyl acetate extracts of Rimulus Cinnamon on systemic inflammation and lung injury in endotoxin-poisoned mice. Drug Chem Toxicol, 42(3):309-316.

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Recombinant Human IL-18 Protein

Recombinant Human IL-18 Protein_SDS