Recombinant Human FLT3 Ligand Protein-T&L T&L

Product Information

Background

FLT3 ligand is a growth factor that regulates the proliferation of early hematopoietic cells. FLT 3-ligand binds to cells expressing tyrosine kinase receptor FLT3. The FLT3 ligand itself does not stimulate the proliferation of early hematopoietic cells, but rather synergistically induces growth and differentiation with other CSFs and interleukins. Unlike SCF, FLT3 ligand has no effect on mast cells. Multiple subtypes of FLT3-ligands have been identified.

The main bioactive form is anchored on the cell surface as the extracellular domain of transmembrane protein (209 a.). The membrane binding isomers can be cleaved by proteins to form biologically active soluble isomers.

References

1. Measurable residual disease (MRD) monitoring by NGS before allogeneic hematopoietic cell transplantation in AML.Thol F, Gabdoulline R, Liebich A, Klement P, Schiller J, Kandziora C, Hambach L, Stadler M, Koenecke C, Flintrop M, Pankratz M, Wichmann M, Neziri B, Büttner K, Heida B, Klesse S, Chaturvedi A, Kloos A, Göhring G, Schlegelberger B, Gaidzik VI, Bullinger L, Fiedler W, Heim A, Hamwi I, Eder M, Krauter J, Schlenk RF, Paschka P, Döhner K, Döhner H, Ganser A, Heuser M.Blood. 2018 Sep 6. pii: blood-2018-02-829911. doi: 10.1182/blood-2018-02-829911.

2. Absence of FLT3 mutations in Iranian adult T-cell leukemia/lymphoma patients.Ayatollahi H, Sadeghian M, Kooshyar M, Shirdel A, Rahimi H, Jafarian A, Ghazaei S, Soltani N, Shams F, Motamedi Rad N, Shakeri S.Med J Islam Repub Iran. 2018 Jun 9;32:47. doi: 10.14196/mjiri.32.47. eCollection 2018.

Document

Recombinant Human FLT3 Ligand Protein

Recombinant Human FLT3 Ligand Protein_SDS