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BMS-906024, Purity: 98.10% Biofargo

Name: Browse our exciting line of BMS-906024, Purity: 98.10% Biofargo . Unique Designs You Can't see anywhere else
SKU: mode_7488792887477
Price: 150.00 USD
Availability: InStock

Original price was: $ 500,00.Current price is: $ 150,00.

Size

Clear

SKU: mode_7488792887477 Category: Uncategorized Tag: chemical

Description:

BMS-906024 is an orally active and selective γ-secretase (gamma secretase) inhibitor. BMS-906024 is a potent pan-Notch receptors inhibitor with IC50s of 1.6 nM, 0.7 nM, 3.4 nM, and 2.9 nM for Notch1, -2, -3, and -4 receptors, respectively. BMS-906024 demonstrates broad-spectrum antineoplastic activity.

For research use only. We do not sell to patients.

Molecular Weight	556.50
Appearance	Solid
Formula	C₂₆H₂₆F₆N₄O₃
CAS No.	1401066-79-2
SMILES	O=C(N[C@@H]1C(N(C)C2=CC=CC=C2C(C3=CC=CC=C3)=N1)=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O
Shipping	Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

IC₅₀ & Target:

IC50: 1.6 nM (Notch1), 0.7 nM (Notch2), 3.4 nM (Notch3) and 2.9 nM (Notch4)

In Vitro:

BMS-906024 (5-100 nM; 72 hours) reduces Notch1 ICD levels in all six lung cancer cell lines. BMS-906024 at 100 nM, has no effect on total Notch1, and down-regulated Hes1 transcript

Cell Line: NSCLC cell lines (A549, H358, H1975, H2444, H1792, HCC44) Concentration: 5, 10, 25, 50, 100 nM Incubation Time: 72 hours Result:

Reduced Notch1 ICD levels in all six lung cancer cell lines tested at concentrations as low as 5 nM, with maximal depletion at 50-100 nM.

In Vivo:

BMS-906024 (8.5 mg/kg; oral gavage; days 1 through 4 of each week for 3 weeks) significantly enhances the tumor growth inhibition of Paclitaxel (36 mg/kg). BMS-906024 enhances Paclitaxel-mediated cytotoxicity in vivo in NSCLC through a combination of inhibiting proliferation and promoting apoptosis, in a p21 and p57-independent manner

Animal Model: Six to 12-week-old female NOD scid gamma (NSG) mice with KRAS- and BRAF-WT PDX-T42 xenografts^{Dosage:
8.5 mg/kg

Administration:
oral gavage; days 1 through 4 of each week for 3 weeks

Result:
Significantly enhanced the tumor growth inhibition of Paclitaxel (36 mg/kg), but had no significant effect on Cisplatin (2 mg/kg) treatment.

Clinical Trial:

NCT Number
Sponsor
Condition
Start Date
Phase

NCT01363817
Bristol-Myers Squibb

Lymphoblastic Leukemia, Acute T-cell|Precursor T-Cell Lymphoblastic Lymphoma

September 28, 2011
Phase 1

NCT01653470
Bristol-Myers Squibb

Cancer

October 12, 2012
Phase 1

NCT01292655
Bristol-Myers Squibb

Cancer

March 3, 2011

Phase 1}

Size	5mg, 10mg, 50mg, 100mg

Quick Shipping and Professional Packaging

We can offer a variety of shipping options due to our long-term relationship with UPS FedEx DHL. Our warehouse staff will package each item according to our strict specifications. Your products will be subjected to a thorough examination and will be safely packaged prior to being shipped. Everyday we deliver thousands of packages to clients across many countries. This is a sign of our determination to become the biggest online retailer in the world. There are distribution centers and warehouses in Europe as well as the USA.

Orders that contain more than 1 item are given processing time for each item.

Before shipment, all ordered items will be thoroughly inspected. Most orders are shipped within 48-hours. Delivery is expected to take between 3 and 7 days.

Returns

The stock market is always changing. It is not managed entirely by us, as we're involved with several parties such as the factory and our storage. The levels of stock can change at any given time. Be aware that it is possible for your order to run out of stock even after you have placed the order.

The policy is 30 days. However, if 30 days have passed since you purchased your item, we will not be able to offer you a return or exchange.

To be eligible for a refund the item must be in good condition and in the same state as when you received it. It should also be in the original package.

BMS-906024, Purity: 98.10% Biofargo

Description:

IC50 & Target:

In Vitro:

In Vivo:

Clinical Trial:

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IC₅₀ & Target: