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Recombinant Human TNF-α Protein-T&L T&L

Name: The latest news from our Recombinant Human TNF-α Protein-T&L T&L
SKU: mode_7522647048373
Price: 84.40 USD
Availability: InStock

Original price was: $ 211,00.Current price is: $ 84,40.

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SKU: mode_7522647048373 Category: Uncategorized Tag: protein

Product Information

Protein sequence	A DNA sequence encoding the human TNF-α (GenBank: ADV31546.2 V77-L233) was expressed with a polyhistidine tag at the C- terminus
Expression Host	HEK293 cells
QC Testing Purity	> 90% as determined by SDS-PAGE
Activity	Measured in a cytotoxicity assay using L-929 mouse fibroblast cells in the presence of actinomycin D. The ED₅₀ for this effect is ≤ 5 ng/mL
Endotoxin Level	< 0.1 EU per μg of the protein as determined by the LAL method
Molecular Mass	The Recombinant protein predicts a molecular mass of 18.2 kD
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 6 % mannitol are added as protectants before lyophilization
Stability & Storage	24 months at 2 °C to 8 °C in lyophilized state. 6 months at -20 °C under sterile conditions after reconstitution. 12 months at -80 °C under sterile conditions after reconstitution. Recommend to aliquot the protein into smaller quantities after reconstituting with water for injection, normal saline or PBS, and keep the diluted concentration above 100 µg/mL. Avoid repeated freeze-thaw cycles.

Background

TNF-α is a pleiotropic pro-inflammatory cytokine secreted by various cells, including adipocytes, activated monocytes, macrophages, B cells, T cells and fibroblasts. It belongs to the TNF family of ligands, and signals through two receptors, TNFR1 and TNFR2. TNF-α is cytotoxic to a wide variety of tumor cells and is an essential factor in mediating the immune response against bacterial infections. TNF-α also plays a role in the induction of septic shock, autoimmune diseases, rheumatoid arthritis, inflammation, and diabetes. TNF-α is produced mainly by macrophages. Large amounts of TNF-α are released in response to lipopolysaccharide, other bacterial products, and Interleukin-1 (IL-1). TNF-α is involved in fighting against tumorigenesis. It is regarded as a potential protein of cancer treatment.

References

Hector J, et al. (2007) TNF-α alters visfatin and adiponectin levels in human fat. Horm Metab Res. 39(4): 250-5.
Berthold-Losleben M, et al. (2008) The TNF-α System: Functional Aspects in Depression, Narcolepsy and Psychopharmacology. Curr Neuropharmacol. 6(3): 193-202.
Zelová H, Hošek J (2013) TNF-alpha signalling and inflammation: interactions between old acquaintances. Inflamm Res 62: 641–651

Document

Recombinant Human TNF-α Protein

Recombinant Human TNF-α Protein_SDS

Size	100μg

Quick Shipping and Professional Packaging

We can offer a variety of shipping options due to our long-term relationship with UPS FedEx DHL. Our warehouse staff will package each item according to our strict specifications. Your products will be subjected to a thorough examination and will be safely packaged prior to being shipped. Everyday we deliver thousands of packages to clients across many countries. This is a sign of our determination to become the biggest online retailer in the world. There are distribution centers and warehouses in Europe as well as the USA.

Orders that contain more than 1 item are given processing time for each item.

Before shipment, all ordered items will be thoroughly inspected. Most orders are shipped within 48-hours. Delivery is expected to take between 3 and 7 days.

Returns

The stock market is always changing. It is not managed entirely by us, as we're involved with several parties such as the factory and our storage. The levels of stock can change at any given time. Be aware that it is possible for your order to run out of stock even after you have placed the order.

The policy is 30 days. However, if 30 days have passed since you purchased your item, we will not be able to offer you a return or exchange.

To be eligible for a refund the item must be in good condition and in the same state as when you received it. It should also be in the original package.

Recombinant Human TNF-α Protein-T&L T&L

Product Information

Background

References

Document

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