Recombinant Human IL-2 Protein-T&L T&L

Product Information

Background

Activated T cells generally cannot survive for a long-time in vitro culture, and the addition of IL-2 can promote their long-term and sustained proliferation. The surface of stationary T cells does not express IL-2R and does not respond to IL-2; T cells activated by mitogen or other stimuli can express IL-2R and become target cells of IL-2; IL-2 can also induce increased IL-2R expression in target cells. The expression of IL-2R on T cells is transient, generally reaching its peak 2-3 days after activation and disappearing around 6-10 days. With the disappearance of IL-2R, T cells lose their ability to respond to IL-2. Therefore, in order to maintain the long-term growth of normal T cells in vitro, it is necessary to constantly stimulate T cells with mitogen or other stimulators to maintain the expression of IL-2R. NK cells are the only lymphoid cells that normally express IL-2R, and therefore always maintain reactivity to IL-2. However, only IL-2R β and γ chains are expressed on stationary NK cells, which have a low affinity for IL-2 and can only react with high concentrations of IL-2. Once NK cells are activated, the IL-2R α Chain is expressed, and IL-2R becomes a high affinity receptor.

References

1. YaoWang, Hanren Dai, Hong Li, Haiyan Lv,TaoWang, Xiaobing Fu,and WeidongHan. Growth of Human Colorectal Cancer SW1116 Cells Is Inhibited by Cytokine-Induced Killer Cells Clinical and Developmental Immunology Volume 2011, Article ID 621414, 9 pages doi:10.1155/2011/621414.

2. D Sangiolo†, G Mesiano, F Carnevale-Schianca, W Piacibello, M Aglietta & A Cignetti . Cytokine induced killer cells as adoptive immunotherapy strategy to augment graft versus tumor after hematopoietic cell transplantation. Expert Opin. Biol. Ther. (2009) 9(7):831-840

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Recombinant Human IL-2 Protein

Recombinant Human IL-2 Protein_SDS

Recombinant Human IL-2 Protein_COA_Pr2306011