Recombinant Human IL-6 Protein-T&L T&L

Product Information

Background

Interleukin 6 (IL-6) is produced by fibroblasts, monocytes, macrophages, T lymphocytes, B lymphocytes, epithelial cells, keratinocytes and various tumor cells. IL-1, TNF-α, PDGF, viral infection, double stranded RNA, and cAMP can all induce normal cells to produce IL-6. IL-6 can stimulate the proliferation, differentiation of immune responses and improve immune cell functions. IL-6R is widely expressed on the surface of activated B cells, quiescent T cells, NK cells, myeloma cells, hepatocytes, and myeloid leukemia cells. The main role of IL-6 is to promote the proliferation and differentiation of B cells and the secretion of antibodies. It also has extensive effects on liver cells, T cells, neural tissue, and hematopoietic system. IL-6 also has anti-tumor effects and can directly or indirectly enhance the tumoricidal activity of NK cells and CTL.

References

1. Ferguson-Smith AC, Chen YF, Newman MS, May LT, Sehgal PB, Ruddle FH (1988)Regional localization of the interferon-beta 2/B-cell stimulatory factor 2/hepatocyte stimulating factor gene to human chromosome 7p15-p21. Genomics 2 (3): 203–8. doi:10.1016/0888-7543(88)90003-1. PMID 3294161.

2. Van der Poll T, Keogh CV, Guirao X, Buurman WA, Kopf M, Lowry SF (1997)Interleukin-6 gene-deficient mice show impaired defense against pneumococcal pneumonia. The Journal of Infectious Diseases 176 (2): 439–44. doi:10.1086/514062. PMID 9237710.

3. Banks WA, Kastin AJ, Gutierrez EG (1994)Penetration of interleukin-6 across the murine blood-brain barrier. Neuroscience Letters 179 (1-2): 53–6. doi:10.1016/0304-3940(94)90933-4. PMID 7845624.

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Recombinant Human IL-6 Protein

Recombinant Human IL-6 Protein_SDS