Recombinant Human 4-1BB Ligand Protein-T&L T&L

Product Information

Background

4-1BB ligand (4-1BBL), also known as CD137L or TNFSF9, is a member of the tumor necrosis factor (TNF) family expressed on activated antigen-presenting cells. Its receptor, 4-1BB, is a member of the TNF receptor family expressed on activated CD4 and CD8 T cells. In response to 4-1BB Ligand binding, 4-1BB transduces a co-stimulatory signal that promotes the proliferation, activation, and survival of CD4+ and CD8+ T cells. T cell co-stimulation through CD28 is important for the initial T cell expansion, while 4-1BB acts later in the response. Furthermore, 4-1BBL may play a role in cognate interactions between T-cells and B-cells/macrophages. As for diseases, 4-1BBL is involved in cancers, infectious diseases and autoimmune diseases.

References

1. 4-1BB Ligand Signaling to T cells Limits T cell Activation So-Young Eun, Seung-Woo Lee, Yanfei Xu, Michael Croft J Immunol. Author manuscript; available in PMC 2016 Jan 1.Published in final edited form as: J Immunol. 2015 Jan 1;194(1): 134–141. Published online 2014 Nov 17. doi: 10.4049/jimmunol.1401383.

2. 4-1BB ligand activates bystander dendritic cells to enhance immunisation in trans Douglas C Macdonald, Alastair Hotblack, Saniath Akbar, Gary Britton, Mary K Collins, William C Rosenberg J Immunol. Author manuscript; available in PMC 2015 May 15.Published in final edited form as: J Immunol. 2014 Nov 15; 193(10): 5056–5064. Published online 2014 Oct 10.doi:10.4049/jimmunol.1301723.

3. A functional recombinant human 4-1BB ligand for immune co-stimulatory therapy of cancer Marcia Meseck, Tiangui Huang, Ge Ma, George Wang, Shu-Hsia Chen, Savio LC Woo J Immunother. Author manuscript; available in PMC 2012 Mar 1.Published in final edited form as: J Immunother. 2011 Mar; 34(2): 175–182. doi: 10.1097/CJI.0b013e318206dac1.

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Recombinant Human 4-1BB Ligand Protein

Recombinant Human 4-1BB Ligand Protein_SDS